My favorite organization is Samaritan's Purse run by Franklin Graham, son of Billy Graham. It is an organization I trust and they give year round, not just during disasters. Based in Boone, NC, it's an organization I got to know while living near there earlier in my life.
The story of the Good Samaritan (Luke 10:30-37) gives a clear picture of God's desire for us to help those in desperate need wherever we find them. After describing how the Samaritan rescued a hurting man whom others had passed by, Jesus told His hearers, "Go and do likewise."They are already there ... we can help them help others.
For over 35 years, Samaritan's Purse has done our utmost to follow Christ's command by going to the aid of the world's poor, sick, and suffering. We are an effective means of reaching hurting people in countries around the world with food, medicine, and other assistance in the Name of Jesus Christ. This, in turn, earns us a hearing for the Gospel, the Good News of eternal life through Jesus Christ.
Bob has listings of other organizations who are helping.